Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells
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چکیده
منابع مشابه
Screening for therapeutic targets of vorinostat by SILAC-based proteomic analysis in human breast cancer cells.
Histone deacetylases (HDACs) play critical roles in silencing tumor suppressor genes. HDAC inhibitors reactivate tumor suppressor genes and inhibit tumor cell growth in vitro and in vivo, and several HDAC inhibitors are currently being evaluated in clinical trials for cancer therapy. A comprehensive analysis of proteins regulated by HDAC inhibitors would enhance our ability to define and charac...
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ژورنال
عنوان ژورنال: PROTEOMICS
سال: 2010
ISSN: 1615-9853
DOI: 10.1002/pmic.200900602